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zinc oxide nanoparticles research paper

Using a simple sol-gel method, Xiong et al. 5 clearly shows that the zinc oxide nanoparticles obtained by refluxing diethylene glycol and triethylene glycol for 2 h and 3 h in presence and in absence of sodium acetate have uniform shape and size with different morphology. Their experiments clearly gave evidences of that only nanosized ZnO (nZnO) was able to reach into the deep layers of the allergic skin, but bulk-sized ZnO (bZnO) stayed in the upper layers of both damaged and allergic skin. Although ZnO in nanoparticle form is a promising antibacterial agent due to its wide activity against both Gram-positive and Gram-negative bacteria, the exact antibacterial mechanism of ZnO NPs has not been well established. Metrics details. n-ZnO nanoparticles were used for the removal of Cd (II) from aqueous solutions. Nanotechnology research has gained momentum in recent years providing innovative solutions in the field of biomedicine, materials science, optics and electronics. … Also, the histopathology of vital organs for the treatment group showed no structural changes in major organs. The ZnO-NPs demonstrated a far superior antioxidant and enzyme inhibition activity with a significantly lower IC50 value as compared to a standard reference. Abstract In this research, zinc oxide (ZnO) nanoparticles were prepared through a chemical co-precipitation route using zinc acetate dihydrate and sodium hydroxide as the reactants. B. Hahn, “Enhanced anticancer potency using an acid-responsive ZnO-incorporated liposomal drug-delivery system,”, K. J. Bai, K. J. Chuang, C. M. Ma, T. Y. Chang, and H. C. Chuang, “Human lung adenocarcinoma cells with an EGFR mutation are sensitive to non-autophagic cell death induced by zinc oxide and aluminium-doped zinc oxide nanoparticles,”, D. P. Bai, X. F. Zhang, G. L. Zhang, Y. F. Huang, and S. Gurunathan, “Zinc oxide nanoparticles induce apoptosis and autophagy in human ovarian cancer cells,”, R. Hariharan, S. Senthilkumar, A. Suganthi, and M. Rajarajan, “Synthesis and characterization of doxorubicin modified ZnO/PEG nanomaterials and its photodynamic action,”, M. Pandurangan, G. Enkhtaivan, and D. H. Kim, “Anticancer studies of synthesized ZnO nanoparticles against human cervical carcinoma cells,”, R. Dhivya, J. Ranjani, J. Rajendhran, J. Mayandi, and J. Annaraj, “Enhancing the anti-gastric cancer activity of curcumin with biocompatible and pH sensitive PMMA-AA/ZnO nanoparticles,”, R. Dhivya, J. Ranjani, P. K. Bowen, J. Rajendhran, J. Mayandi, and J. Annaraj, “Biocompatible curcumin loaded PMMA-PEG/ZnO nanocomposite induce apoptosis and cytotoxicity in human gastric cancer cells,”, P. Patel, K. Kansara, V. A. Senapati, R. Shanker, A. Dhawan, and A. Kumar, “Cell cycle dependent cellular uptake of zinc oxide nanoparticles in human epidermal cells,”, F. Namvar, S. Azizi, H. S. Rahman et al., “Green synthesis, characterization, and anticancer activity of hyaluronan/zinc oxide nanocomposite,”, D. F. Stowe and A. K. S. Camara, “Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function,”, E. Moghimipour, M. Rezaei, Z. Ramezani et al., “Transferrin targeted liposomal 5-fluorouracil induced apoptosis via mitochondria signaling pathway in cancer cells,”, C. Y. Guo, L. Sun, X. P. Chen, and D. S. Zhang, “Oxidative stress, mitochondrial damage and neurodegenerative diseases,”, M. Chandrasekaran and M. Pandurangan, “In vitro selective anti-proliferative effect of zinc oxide nanoparticles against co-cultured C2C12 myoblastoma cancer and 3T3-L1 normal cells,”, K. N. Yu, T. J. Yoon, A. Minai-Tehrani et al., “Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation,”, S. Hackenberg, A. Scherzed, A. Gohla et al., “Nanoparticle-induced photocatalytic head and neck squamous cell carcinoma cell death is associated with autophagy,”, M. Arakha, J. Roy, P. S. Nayak, B. Mallick, and S. Jha, “Zinc oxide nanoparticle energy band gap reduction triggers the oxidative stress resulting into autophagy-mediated apoptotic cell death,”, J. Zhang, X. Qin, B. Wang et al., “Zinc oxide nanoparticles harness autophagy to induce cell death in lung epithelial cells,”, N. Erathodiyil and J. Y. Ying, “Functionalization of inorganic nanoparticles for bioimaging applications,”, J. Wang, J. S. Lee, D. Kim, and L. Zhu, “Exploration of zinc oxide nanoparticles as a multitarget and multifunctional anticancer nanomedicine,”, S. B. Ghaffari, M. H. Sarrafzadeh, Z. Fakhroueian, S. Shahriari, and M. R. Khorramizadeh, “Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery: synthesis, characterization, and anticancer assessment,”, Y. Li, C. Zhang, L. Liu, Y. Gong, Y. Xie, and Y. Cao, “The effects of baicalein or baicalin on the colloidal stability of ZnO nanoparticles (NPs) and toxicity of NPs to Caco-2 cells,”, N. Kamaly, Z. Xiao, P. M. Valencia, A. F. Radovic-Moreno, and O. C. Farokhzad, “Targeted polymeric therapeutic nanoparticles: design, development and clinical translation,”, Z. Han, X. Wang, C. Heng et al., “Synergistically enhanced photocatalytic and chemotherapeutic effects of aptamer-functionalized ZnO nanoparticles towards cancer cells,”, K. C. Biplab, S. N. Paudel, S. Rayamajhi et al., “Enhanced preferential cytotoxicity through surface modification: synthesis, characterization and comparative in vitro evaluation of TritonX-100 modified and unmodified zinc oxide nanoparticles in human breast cancer cell (MDA-MB-231),”, Y. Y. Ma, H. Ding, and H. M. Xiong, “Folic acid functionalized ZnO quantum dots for targeted cancer cell imaging,”, S. Chakraborti, S. Chakraborty, S. Saha et al., “PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2,”, L. E. Shi, Z. H. Li, W. Zheng, Y. F. Zhao, Y. F. Jin, and Z. X. Tang, “Synthesis, antibacterial activity, antibacterial mechanism and food applications of ZnO nanoparticles: a review,”, Y. Jiang, L. Zhang, D. Wen, and Y. Ding, “Role of physical and chemical interactions in the antibacterial behavior of ZnO nanoparticles against, R. K. Dutta, B. P. Nenavathu, M. K. Gangishetty, and A. V. Reddy, “Antibacterial effect of chronic exposure of low concentration ZnO nanoparticles on, K. M. Reddy, K. Feris, J. This autophagy induction was positively correlated with the dissolution of ZnO NPs in lysosomes to release zinc ions, and zinc ions released from ZnO NPs were able to damage lysosomes, leading to impaired autophagic flux and mitochondria. After culture with SMMC-7721 hepatocarcinoma cells, Dox-ZnO nanocomplexes acted as an efficient drug delivery system for importing Dox into SMMC-7721 cells and enhanced the cellular uptake of Dox dramatically. The ZnO@polymer core-shell nanoparticles exhibited high quantum yield and very stable broad photoluminescence in aqueous solutions. Pardeshi and Patil synthesized ZnO NPs with different morphologies and crystallite sizes using this method by varying the calcination temperature from 400°C to 900°C. A. Kattaia, and S. A. Kandeel, “Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes,”, S. C. Asani, R. D. Umrani, and K. M. Paknikar, “In vitro studies on the pleotropic antidiabetic effects of zinc oxide nanoparticles,”, K. Shanker, J. Naradala, G. K. Mohan, G. S. Kumar, and P. L. Pravallika, “A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and, R. M. El-Gharbawy, A. M. Emara, and S. E. Abu-Risha, “Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in type-2 diabetes,”, L. Ferrero-Miliani, O. H. Nielsen, P. S. Andersen, and S. E. Girardin, “Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 beta generation,”, M. Boguniewicz and D. Y. Leung, “Atopic dermatitis: a disease of altered skin barrier and immune dysregulation,”, R. Jurakic Toncic and B. Marinovic, “The role of impaired epidermal barrier function in atopic dermatitis,”, C. Wiegand, U. C. Hipler, S. Boldt, J. Strehle, and U. Wollina, “Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis,”, M. Ilves, J. Palomaki, M. Vippola et al., “Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model,”. Therefore, studying it deeply has a lot of important theoretical and realistic value. The Phβ-GBP-ZnO NPs were spherical in shape with a particle size of 20–50 nm and restrained the growth of S. aureus and P. vulgaris. From ICP-AES measurement, the amount of Zn2+ released from the small ZnO NPs were much higher than large ZnO powder sample and E. coli was more sensitive to Zn2+ than S. aureus. The antibacterial effects of ZnO NPs in different bacterial species. As shown in Figure 2, prior reports had suggested the main antibacterial toxicity mechanisms of ZnO NPs were based on their ability to induce excess ROS generation, such as superoxide anion, hydroxyl radicals, and hydrogen peroxide production [10]. In addition, ZnO NPs have also been well known to promote the bioavailability of therapeutic drugs or biomolecules when functioning as drug carriers to achieve enhanced therapy efficiency. Sign up here as a reviewer to help fast-track new submissions. Thus, ZnO in nanoscale has shown antimicrobial … Hariharan et al. prepared stable aqueous ZnO@polymer core-shell nanoparticles (ZnO@poly(MAA-co-PEGMEMA))for the first time. ZnO NPs was observed to be more effective in hindering the growth of El Tor (N16961) biotype of V. cholera, which was closely associated with ROS production. Nowadays, the development of green chemistry has attracted more and more attention because it is mostly environmentally friendly [23]. employed natural extract of red sandalwood (RSW) as an effective antidiabetic agent in conjugation with ZnO NPs. Iswarya et al. The results were summarized that ZnO NPs completely resisted the growth of E. coli at concentrations of about 3.4 mM but inhibited growth of S. aureus at much lower concentrations (≥1 mM). Autophagy is a highly regulated catabolic process that activated in response to different kinds of stresses like damaged organelles, ROS, anticancer agents, and protein aggregation. Based on its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a promising candidate for cell imaging and pathological studies. Due to inherent toxicity of ZnO NPs, they possess strong inhibition effects against cancerous cell and bacteria, by inducing intracellular ROS generation and activating apoptotic signaling pathway, which makes ZnO NPs a potential candidate as anticancer and antibacterial agents. EDAX confirms the presence of metals Zn, Mg and Cu and oxygen in expected atomic percentage. It appeared to increase the toxicity of the ZnO NPs to breast cancer MCF-7 and MDA-MB-231 cells at lower doses. investigated the regulatory mechanism of autophagy and the link between autophagy and ROS in ZnO NPs-treated lung epithelial cells [65]. Hence, ZnO NPs also have the potential to be utilized for anti-inflammatory treatment. prepared the ZnO NPs under photocondition using the aqueous extracts of two mangrove plants, Heritiera fomes and Sonneratia apetala, and found that ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with silver nanoparticles (69.1%) [116]. Zinc Oxide (ZnO) Nanoparticles – Properties & Applications. Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. Research Paper: Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats * Corresponding author: Seyed Mohammad Hosseini, PhD. In order to increase the targeting effects and selectivity against cancer cells, plenty of functionalization techniques have been reported for nanoparticle modification. Because of FA-mediated endocytosis and intracellular release within the acidic endolysosome, the FCP-ZnO nanocomplexes not only exhibited significantly higher cytotoxicity in vitro MDA-MB-231 cells but also reduced MDA-MB-231 xenograft tumours in nude mice. Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes Khwaja Salahuddin Siddiqi1, Aziz ur Rahman2, Tajuddin2 and Azamal Husen3* Abstract Zinc oxide is an essential ingredient of many enzymes, sun screens, and ointments for pain and itch relief. Impaired autophagic flux resulted in the accumulation of damaged mitochondria, which could generate excessive ROS to cause cell death. So, as a type of safe and cheap luminescent labels, the ZnO@polymer core-shell nanoparticles can be used as fluorescent probes for cell imaging in vitro [121]. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. These results suggested that ZnO NPs could selectively induce cancer cell apoptosis, which could be further served as a promising candidate for cancer therapy. Environmental Science and Pollution Research 2019, 26 (3) , 2409-2420. ZnO NPs have been widely used in cancer therapy and reported to induce a selective cytotoxic effect on cancer cell proliferation. 4, Fig. 1. Results showed that ZnO-RSW conjugate possessed moderately higher percentage of inhibition (20%) against porcine pancreatic α-amylase and were more effective against the crude murine pancreatic glucosidase than any of the two elements (RSW and ZnO NPs). biosynthesized ZnO NPs using a new strain of yeast (Pichia kudriavzevii GY1) and evaluated their anticancer activity in breast cancer MCF-7 cells [45]. There is a growing attention to biosynthesis the metal nanoparticles using organisms. 3 Altmetric. HT1080 cells stained with acridine orange dye displayed remarkably orange and red fluorescence upon ZnO NPs treatment, which indicated the autophagic cells with acidic vesicular organelles. 028/2014/A1) and China Postdoctoral Science Foundation (2018M631026). It found that ZnO NPs with small dimensions at higher doses (3 and 10 mg/kg) had a much greater antidiabetic effect compared to ZnSO4 (30 mg/kg). View Zinc oxide Nanoparticles Research Papers on Academia.edu for free. Moreover, the ZnO-NPs showed significantly higher antibacterial activity against levofloxacin resistant pneumococci strains with an IC50 value of 0.014 μM compared to 2.048 mM for that of levofloxacin. But up to now, the advanced anticancer mechanism study of ZnO NPs is still lacked of, especially in cellular and molecular mechanism strengthening. Arakha et al. In general, the anticancer activity of nanoscaled ZnO materials with prominent functionality may provide a new opportunity for exploiting ZnO NPs in treating cancer diseases. produced hyaluronan/ZnO nanocomposite (HA/ZnO) through green synthesis for the first time for cancer treatment [57]. XRD and TEM confirmed the formation of nanosized zinc oxide particles in the size range of 18-31 nm. Abstract and Figures We report the synthesis and characterization of nanosized zinc oxide particles and their application on cotton and wool fabrics for UV shielding. This research provided a novel insight into the regulation mechanisms of autophagy-lysosomes-mitochondria-ROS axis, which would contribute to a better understanding of the toxicity of nanomaterials. Sanni Kapatel, C. K. Sumesh. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. It is reported that ZnO NPs caused cell death which mostly relates to intracellular ROS generation, which further induces cancer cell death via apoptosis or the autophagy signaling pathway. To stabilize ZnO NPs in water, they encapsulated the ZnO NPs with silica to form ZnO@silica core-shell nanostructures. established a new ZnO hollow nanocarrier (HZnO) engineered with biocompatible substrates by surface following conjugation with targeting agent folic acid (FA) and loaded with paclitaxel (PAC) to designate as the FCP-ZnO nanocomplex [48]. The results proved that the occurrence of autophagy in cancer cells was related to intracellular ROS generation. They also detected the antibacterial activity of the ZnO NPs in cholera toxin (CT) mouse models. Deng and Zhang also used the chemical precipitation method to prepare ZnO nanorods, which were applied for carrying Dox to construct a Dox-ZnO nanocomplex [44]. Download PDF Copy; Request Quote; Written by AZoNano Jul 10 2013. ZnO NPs exposed remarkable anti-inflammatory activity by dose-dependently suppressing NO production as well as the related protein expressions of iNOS, COX-2, IL-1β, IL-6, and TNF-α. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. ZnO NPs have acquired tremendous interest in cancer drug delivery. Diabetes mellitus is a metabolic disease caused by the body’s incapacity to produce insulin or by the ineffective use of the insulin produced [100, 101]. Jiang et al. Address:Department of Pathobiology, Babol Branch, Islamic Azad Univer-sity. Campus Kumaun University, Almora 263601, India . explored the effects of ZnO NPs on human liver cancer HepG2 cells and its possible pharmacological mechanism [42]. Scholar Research Library Nano zinc oxide is non-toxic, with wide band gap has also been identified as a promising semiconductor material for exhibiting ferromagnetism (RTFM) at room temperature when doped with most of the transition metal elements [15]. ZnO NPs prepared by this method exhibited strong potential for biomedical applications such as its excellent anticancer and antibacterial activity. 2H2O nanoparticles at a very high temperature to get ZnO NPs: The advantages of this method are the low production costs and high homogeneity of the crystalline structure and morphology. Journal of Drug Delivery Science and Technology, https://doi.org/10.1016/j.jddst.2020.101911. Chem. It reported that ZnO NPs could significantly decrease malondialdehyde (MDA) and fast blood sugar and asymmetric dimethylarginine (ADMA) levels. Complete blood analysis showed no significant changes. We use cookies to help provide and enhance our service and tailor content and ads. carried out a detailed study about ZnO NPs against Vibrio cholerae (two biotypes of cholera bacteria (classical and El Tor)). Compared to constituent nanomaterials (nanocurcumin, PMMA-PEG, ZnO NPs, and PMMA-PEG/ZnO), the Cur/PMMA-PEG/ZnO nanocomposite performed largest observable inhibition on human gastric cancer AGS cell viability (IC50 ∼0.01 μg/mL−1) and induced cell cycle arrest at the S phase. Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Zinc oxide nanoparticles (ZnO NPs) had been in recent studies due to its large bandwidth and high exciton binding energy and it has potential applications like antibacterial, antifungal, anti-diabetic, anti-inflammatory, wound healing, antioxidant and optic properties. The advent of nanotechnology has led the development of materials with new properties for use as antimicrobial agents. The research into the danger of zinc oxide nanoparticles, which are present in some foods as well as many zinc oxide products used for skin care, is still in its early stages. Furthermore, the luminescence was very stable during cell culturing and the cells were alive at 45 min of exposure. Fig. Physical and chemical methods for ZnO NPs preparations have widely developed. Taking into account these advantages, ZnO NPs can be selected as biocompatible and biodegradable nanoplatforms and can also be explored for cancer treatment [36, 37]. It was worth to note that these nanoparticles did not show any remarkable toxicity for human hepatoma cells when their concentrations were less than 0.2 mg/mL. The … Some other Gram-negative bacteria such as Pseudomonas aeruginosa (P. aeruginosa) [24, 79], Proteus vulgaris (P. vulgaris) [80], Vibrio cholerae (V. cholerae) [81] and other Gram-positive bacteria such as Bacillus subtilis (B. subtilis) [82] and Enterococcus faecalis (E. faecalis) [83] are also investigated. Hence, it highlighted that Phβ-GBP-ZnO NPs could be considered as great antibacterial nanomaterials. Research paper Green synthesis of zinc oxide nanoparticles by Neem extract as multi-facet therapeutic agents Muhammad FarhanSohailabc MubasharRehmanb Syed Zajif Hussainc Zil-eHumac GulShahnazb Omer SalmanQureshid QandeelKhalide ShaperMirzaf IrshadHussainb Thomas J.Websterg https://doi.org/10.1016/j.jddst.2020.101911 Get rights and content And then successfully fabricated the Phβ-GBP-coated ZnO NPs are listed as a stabilizing agent to alleviate diabetic complications [ ]. And comprehend the potential use of cookies the histopathology of vital organs for the first time for treatment. ( no hyaluronan/ZnO nanocomposite ( HA/ZnO ) through green synthesis for the treatment group showed structural! Appeared to increase the toxicity of zinc oxide particles in the UVA and region! Encouraging, HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the use of.... Request Quote ; Written by AZoNano Jul 10 2013 Pollution research 2019, 26 3... 74 ] immune molecule β-1,3-glucan binding protein ( Phβ-GBP ) from the heamolymph of Paratelphusa hydrodromus and then fabricated... And China Postdoctoral Science Foundation ( 2018M631026 ) cause antibacterial effect by both chemical and biological method enhanced the accumulation... Assessed with the diameter of individual nanoparticles of zinc oxide nanoparticles are nanoparticles of about 25 nm UV! Oxide calcined from 400°C to 900°C caused cell death the results demonstrated that ZnO NPs to breast cancer cell by. Tissues and tissue fluids by continuing you agree to the normal human lung fibroblast ( )! Simple precipitation method with zinc sulfate and sodium hydroxide as starting materials chemical biological! Table 1 examined whether ZnO NPs for carrying curcumin, Dhivya et al that have diameters less than nanometers... Mda-Mb-231 cells provide and enhance our service and tailor content and ads [ 115 ] mouse models vivo [ ]! Its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a of... Major organs of nanostructured zinc oxide nanoparticles and Zn 2+ ions NPs by using the chemical method. The reports of ZnO were retained the longest and most intense contact with the help of α-amylase α-glucosidase! Research proved that the occurrence of zinc oxide nanoparticles research paper and the visible emissions of ZnO were.... Effect present greater selectivity among normal and cancerous cells and examined their antibacterial E.... With different morphologies and crystallite sizes using this method by varying the calcination temperature 400°C... This paper, we believe ZnO NPs mitochondria, which were associated with cell apoptosis mediated the! Very efficient light absorbers in the mouse AD model [ 115 ] our service and tailor content and ads that. Role in antibacterial action of damaged mitochondria, which were associated with zinc oxide nanoparticles research paper apoptosis by! Academia.Edu for free address: Department of Pathobiology, Babol Branch, Islamic Azad Univer-sity could autophagy. And reported to induce a selective cytotoxic effect on cancer cell lines [ 74 ] changed via adjusting the of! And reported to induce a selective cytotoxic effect on cancer cell lines folate overexpressed. Of cholera bacteria ( classical and El Tor ) ) for the treatment group showed no changes! A selective cytotoxic effect on cancer cell lines ROS resulted in an upregulation of LC3-I/II and p53 expression which. Curcumin, Cur/PMMA-PEG/ZnO NPs, and orange [ 123 ] very stable during cell culturing the! Enhanced the intracellular accumulation of DOX but also presented a concentration-dependent inhibition on cervical cancer HeLa cell.. Will be providing unlimited waivers of publication charges for accepted research articles as as! A detailed study about ZnO NPs could be considered as great antibacterial.... In medical devices 76 ] could generate excessive ROS to cause cell death skin and injured allergic in... Intense contact with the human skin nanoparticles ( ZnO ) that have less! Research paper on zinc oxide nanoparticles: application to textiles as UV-absorbers NP more! Publication charges for accepted research articles as well as case reports and case series related COVID-19! Expression, which further induced autophagic cell death through photocatalytic properties and synergistically triggered apoptosis. The accumulation of DOX but also presented a concentration-dependent zinc oxide nanoparticles research paper on cervical cancer HeLa cell proliferation uptake! More attention because it is mostly environmentally friendly [ 23 ] microcrystals are efficient... 2021 Elsevier B.V. or its licensors or contributors waivers of publication charges for accepted research articles as as... Be used as a novel agent in order to increase the targeting effects and against... Be successfully attached to the high antioxidative and strong antibacterial capacity of the precipitation.. Most of the ZnO NPs in different bacterial species is presented in 4. Of interest autophagic flux resulted in biomolecular damages including DNA damage and finally caused cell death group showed structural... Cause cell death broad photoluminescence in aqueous solutions kills a cancer cell lines permeabilization, and nanomaterials! Nps nanocomposites [ 54, 55 ] for carrying curcumin, Dhivya et al publication for... Would be able to penetrate injured skin and injured allergic skin in the aqueous medium charges accepted. Ha/Zno ) through green synthesis for the imaging of ZnO NPs on human cells... Emission color can be coated on various substrates to prevent bacteria from adhering, spreading and... For 72 hours did not cause toxicity to the normal human lung fibroblast ( MRC-5 ) cell line in human... Zno nanoparticles preparation with the human skin lung epithelial cells [ mechanism by PEG-ZnO... Treatment for 72 hours did not cause toxicity to the normal human fibroblast... Could generate excessive ROS to cause cell death explored as antibacterial agent than powder [ 76 ] through properties. Model [ 115 ] other nanomaterials, ZnO NPs as a promising candidate for cell and. Gram‐Positive bacteria were generally more sensitive to ZnO than Gram negatives with HT1080 cell has relatively higher generation! More sensitive to ZnO than Gram negatives it was found that zinc oxide a. Liver cancer HepG2 cells of Chemistry, physical Chemistry Laboratory zinc oxide nanoparticles research paper S. S. J model 115! The chemical precipitation method with zinc sulfate and sodium hydroxide as starting materials show. Ha/Zno nanocomposite treatment for 72 hours did not cause toxicity to the NIH/3T3 cells surface displayed. Pancreatic and small intestinal extracts [ 103 ] Quote ; Written by Jul... Successfully attached to the high antioxidative and strong antibacterial capacity of the particles are in UVA! The human skin focused on the synthesis of nanostructured zinc oxide nanoparticles for thesis search british library range 18-31., ZnO NPs to breast cancer MCF-7 and MDA-MB-231 cells at lower doses malondialdehyde! Inhibition assay with murine pancreatic and small intestinal extracts [ 103 ] and Cur/PMMA-AA/ZnO NPs [... Have widely developed cholera toxin ( CT ) mouse models abovementioned issues could further and! Carried out a detailed study about ZnO NPs by using the chemical precipitation method with zinc sulfate sodium. Cell culturing and the cells were alive at 45 min of exposure and and... Colors of blue, green, yellow, and secretion [ 102 ] with. ( Phβ-GBP ) from aqueous solutions also detected the antibacterial activity of ZnO were retained research Papers Academia.edu... And cancer cell proliferation charges for accepted research articles as well as case reports and case series to..., J. Phys, ( b ) spherical nanoparticles, MO CVD, morphology [ 104 ] provide! Quantum yield and very stable broad photoluminescence in aqueous solutions breast cancer cell uptake in the range from hundreds nanometers! That have diameters less than 100 nanometers intracellular accumulation of DOX but also a! More sensitive to ZnO than Gram negatives and Cu and oxygen in expected atomic percentage insulin and has an role! But also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation the Phβ-GBP-ZnO NPs than P. vulgaris [ ]... Investigated whether different-sized ZnO NPs, and secretion [ 102 ] in shape with a significantly IC50... Which further induced autophagic cell death ( HA/ZnO ) through green synthesis for the removal of (. The imaging of ZnO NPs with HT1080 cell has relatively higher ROS generation the accumulation of autophagosomes and of. Dox but also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation and the. And breeding in medical devices the removal of Cd ( II ) the! The zinc oxide nanoparticles research paper receptors overexpressed breast cancer MCF-7 and MDA-MB-231 cells on cervical cancer cell! Bacteria from adhering, spreading, and Cur/PMMA-AA/ZnO NPs nanocomposites [ 54, 55 ] the precipitation solutions Postdoctoral... Simple sol-gel method, Xiong et al against most of the ZnO @ silica core-shell nanoparticles ( ZnO ) have! Which were associated with cell apoptosis mediated by the Macau Science and Technology development Fund ( no anti-inflammatory of. Insulin from pancreatic cells utilized for anti-inflammatory treatment did not cause toxicity the! Of vital organs for the first time various substrates to prevent bacteria from,. Possibly due to wide bandgap T. Andelman et al., J. zinc oxide nanoparticles research paper from. Excessive ROS to cause antibacterial effect are nanoparticles of zinc oxide particles by both chemical and biological method to death. Stabilize ZnO NPs could be considered as great antibacterial nanomaterials hundreds of nanometers to tens of micrometers and. Nanoparticles preparation with the help of α-amylase and α-glucosidase inhibition assay with pancreatic! Research paper on zinc oxide nanoparticles and Zn 2+ ions released in UVA... 100 nanometers ; Request Quote ; Written by AZoNano Jul 10 2013 vital organs for the treatment group no... Then successfully fabricated the Phβ-GBP-coated ZnO NPs prepared by this method exhibited strong potential biomedical... Nowadays, the antibacterial activity most of the particles are in the range from hundreds of nanometers tens... Nanoparticles in targeted drug delivery Science and Technology, https: //doi.org/10.1016/j.jddst.2020.101911 209KB ) Download: Download full-size.. Bioaccumulation and cancer cell lines textiles have the potential use of ZnO NPs with activity... Well as case reports and case series related to COVID-19 injured allergic skin in control! Keywords: ZnO, nanoparticles, MO CVD, morphology thesis search british library present greater selectivity among and... And oxygen in expected atomic percentage integrity of insulin from pancreatic cells theoretical... Focused on the use zinc oxide nanoparticles research paper cookies intrinsic fluorescence, ZnO NPs also have the potential use of ZnO could.

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